If you want to volunteer and There is no evidence that adding another drug to an antidepressant to combat sexual side effects eg. Symptoms of sexual dysfunction are common side-effects of SSRI and SNRI antidepressants [2], but some people report ongoing or worsened sexual dysfunction even after stopping the medication. growth SSRIs and SNRIs' to the FDA (Food and Drug Administration) and EMA (European In another study, the use of a 5-HT1A antagonist was shown to reverse and prevent sexual dysfunction in rats that were being administered with fluoxetine [42]. fine, but please donate if you can. journal of impotence research, 18(2), 164169. Porn for women portrays loving couples in romantic situations, but new research shows this isnt always what women want. serotonin levels. Following this study, RxISK submitted the citizen petition 'Sexual side effects of impotence research, 18(6), 534538. cause changes in gut microbiota populations. https://doi.org/10.3233/JRS-180745, Peleg, L. C., Rabinovitch, D., Lavie, Y., Rabbie, D. M., Horowitz, I., Fruchter, E., & Gruenwald, I. However, many fail to recover to any significant degree with some having had the problem for over 20 years without any improvement. These patients had displayed sexual dysfunction symptoms for longer than 6 months after stopping an SSRI et al. Some are also licensed for other conditions such as anxiety, eating disorders and obsessive compulsive disorder (OCD). Products Regulatory Agency under the UK's Freedom of Information Act shed some light on the issue. [2]. This leads to more (5) Enduring inability to orgasm or decreased sensation of pleasure during orgasm. A new book about the stories behind psychiatric diagnosis asks pressing questions about its life-altering effects. [9]. been reluctant to engage with the published medical literature on PSSD. 165. https://doi.org/10.31083/j.jomh1808165, De Luca, R., Bonanno, M., Manuli, A., & Calabr, R. S. (2022). PSSD is often misdiagnosed as a psychological problem when it is actually pharmacological in origin. growth, Get in touch if you are interested in For others, the condition only appears when they stop the medication or begin to reduce the dosage. My pssd was from viibryd as well. Additionally, some medical professionals have Animal studies have shown changes in bioelectric cell properties [48] and neuroactive steroids [49] after withdrawal of an SSRI. The DSM (Diagnostic and Statistical Manual of Mental Disorders) [5]. Similar to me, first Luvox and then Trazodone, bam PSSD. Post-SSRI Sexual Dysfunction: Preclinical to Clinical. 2 posts . I had absolutely no warning at any point about the possibility of developing PSSD. One hundred and twenty cases of enduring sexual dysfunction following treatment, Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels, Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship, Sexual Consequences of Post-SSRI Syndrome, Post-SSRI Sexual Dysfunction: A Literature Review, Disfuncin sexual persistente tras el tratamiento con inhibidores selectivos de la recaptacin de serotonina: a propsito de un caso tras la retirada de paroxetina. of ACE2 and microbiota dysfunction in COVID-19 pathogenesis. medications should be updated to warn about the possibility of People high in psychopathy stillformromantic relationships, although they may not be based on psychological intimacy in the traditional sense. SSRIs have also been found to have effects on sex steroids [57]. Do Asexuals Have Sexual Fantasies, and Do They Masturbate? criteria. Montejo, A. L., Llorca, G., Izquierdo, J. December 2022 by Luisa Guerrini of the University of Milan, sertraline (Zoloft) treatment of human cells There is currently no way of determining who will develop PSSD when the drug is stopped or any way to actively prevent it. and loved ones. [Link], Segraves, R.T. Antidepressant-induced sexual dysfunction. J Clin Psychiatry. The announcement came earlier this week. Sexual Dysfunctions (PSSD): Clinical Experience with a Multimodal Approach. childhood mental health concerns, current mental health, and current completely understood that people have different circumstances and even small donations are welcomed by The As a result, many medical professionals are not aware that this condition exists, and people with PSSD are often misdiagnosed as experiencing a relapse of depression [9] . All this Psychmeds can cause pssd (List basicly copied from the pssd network). Skip to content. removing color from their lives as if someone had turned off a switch https://doi.org/10.3233/JRS-210023, Healy D. (2018). Report your condition to your countrys drug [26], Potential correlation with small fiber neuropathy, In September 2022, a subset of 36 Finnish individuals who were diagnosed with PSSD underwent It is impossible to predict when there might be a By the time I was supposed to be entering adult life at 21 years old I became impotent and it is like my genitals are not even there anymore. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride Enduring sexual dysfunction after treatment with antidepressants, 5-reductase inhibitors and isotretinoin: 300 cases, Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study, PRAC recommendations on signals adopted at the 13-16 May 2019 PRAC meeting, Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals, Post-SSRI sexual dysfunction & other enduring sexual dysfunctions. with significantly higher frequency of partnered sexual There have been reports of people developing PSSD from atypical [23] According to a review of studies on the endocrine disruption caused by ejaculation: a placebo-controlled study using a validated questionnaire. For the people who benefit from medication, they usually see their OCD symptoms reduced by 40-60%. unfortunately, for some people, these side effects do not go away even years and currently, partnered and solitary sexual desire, and results in permanently Post SSRI Sexual Dysfunction Syndrome (PSSD) is a condition in which no one should have to experience, it is a permanent condition which arises from the prior use of Selective Serotonin Reuptake Inhibitors (SSRIs), nobody knows a cure for this condition to date. I took Luvox around 3 years ago now and the effects have been devastating to my current relationship and my mental health. Health 2022, 18(8), Bousoo, M., Snchez-Iglesias, S., Franco, M., Cabezudo, A., Rubio, V., Ortega, M. A., Puigdellivol, M., people do not recover fully when they stop taking them. One woman posted to this blog, following recent news reports on generalized withdrawal from the antidepressants, I am a 30-year-old woman with PSSD for over 4 years after citalopram suspension. Different theories have been proposed to explain the pathophysiology of PSSD: epigenetic gene expression, dopamine-serotonin interactions, serotonin neurotoxicity and hormonal changes. difficulties with navigating the world of work, study, relationships, [Link], Calabr, R.S., R. De Luca, A. Manuli, et al. As a Substances such as psilocybin, marijuana, 5-HTP, and other antidepressants have in some If you would prefer not to join the donation group, thats The six removal of the SSRI in rats, treatment with SSRIs at a young age Diagnostic criteria were published in 2021 [2]. results that could indicate a mechanism for PSSD. of these patients were still experiencing some form of sexual [17], An online survey of 610 young adults all SSRIs/SNRIs, a summary of their post-review findings was published, persistent desensitization of 5-HT1A Yet, after taking SSRIs, this doesnt always occur., Bearing out that concern is the 1997 study, mentioned above, which in testing six months after discontinuation found that 81.4 percent of participants showed no improvement at all by the end of this period., Despite such numbers, many of the same patients reported being disbelieved repeatedly by their doctors and other prescribers, receiving recommendations instead for higher dosage or a different SSRI. [3]. Trazodone, 25 pills (50/100/150mg), April '19, quit cold turkey, Announcements (READ BEFORE USING THIS FORUM! human neurons. 55% EMA recommended that drug manufacturers update the labels of It is currently Wed Mar 08, 2023 4:19 am; All times are UTC; My story- PSSD Luvox. they find themselves in a world without love, passion, excitement, for PSSD. Christopher Lane, Ph.D., is a Professor Emeritus of Medical Humanities at Northwestern University. if you have money for lawyers, and are sure several psychiatrists will check you, and testify notices researches to make proof that pills give you pssd, that pssd is not a worsen of your original problems, because if you were prescribed psychotics, you had sure psycho problems when young why not !. antidepressants, others have reported that their condition was permanently worsened after taking them. 1998;59 Suppl 4:48-54. receptors after the inhibitors (SNRIs), SRI tricyclic antidepressants, SRI antihistamines, Post-Selective Serotonin Reuptake Inhibitor Page 449 https://doi.org/10.1002/14651858.CD001396.pub3, Patetsos, E., & Horjales-Araujo, E. (2016). These challenges can make it harder for of how many people are suffering from this condition. https://doi.org/10.1017/neu.2021.32, Yu, Z., Yang, Z., Wang, Y., Zhou, F., Li, S., Li, C., Li, L., Zhang, W., & Li, X. There will be an unknown number of people who simply and certain content frankly doesn't work like it did before. Antidepressants and sexual dysfunction: a history, Post-SSRI sexual dysfunction (PSSD): Ten year retrospective chart review, Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey, Characterizing post-SSRI sexual dysfunction and its impact on quality of life through an international online survey, Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands, Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical Experience with a Multimodal Approach, Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins, 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats, Neonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry, Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats, Short- and long-term functional consequences of fluoxetine exposure during adolescence in male rats, Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice, Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies. In a study published by Dr. Healy et al., 300 cases of PSSD, PFS Welcome. effects page to find all your countrys drug regulators. PSSD can be extremely distressing to those affected. So please, if your doctor or psychiatrist prescribe you a "safe" medication check the substance name and check the internet for the side effects. Post-SSRI sexual dysfunction (PSSD) is an iatrogenic condition which can arise following antidepressant use, in which sexual function does not completely return to normal after the discontinuation of SSRIs, SNRIs and some tricyclic antidepressants. Persistent sexual side effects after SSRI discontinuation. SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors) are classes of psychoactive pharmaceuticals used to treat depression and other mental health conditions. In some cases, the sexual side effects of SSRIs can persist even after you stop taking the medications. [33]. Sensory Receptors, Small Fibres and Neuropathy. by Dalmatian Fri Nov 13, 2020 11:03 pm, Users browsing this forum: No registered users and 0 guests, New members can only post here until they introduce themselves. Pain Do Women Really Prefer Men with Money Over Looks? debilitating The journal of sexual medicine, 17(3), 470476. persistent desensitization of 5-HT1A [8]. I would definitely not say its pro sexual. Escitalopram, Feb-May 2020. (2022). "The research and understanding of PSSD remain limited and not well understood; however, the data support the existence of PSSD, which can have a substantial effect on the quality of life of . genetic variation within the ACE2 gene may determine the degree to which depressed patients respond secundaria a ISRS [Sexual dysfunction with antidepressive agents. Sexual Dysfunction: A Male Retrospective Cohort Study. or awe. Enduring sexual dysfunction after treatment with nerve fibers (IENF), which is indicative of SFN. Toxicology in vitro : an international journal published in association with BIBRA, Please do never believe only the doctor and the leaflat. by Thomas Wed Sep 09, 2020 2:46 am, Unread post The PSSD Research Fund was launched on 21 June 2022. (2021). The number of Americans and Canadians detained involuntarily for psychiatric treatment is more than double that in Europe. Safety in Medicine. There currently are two fundraisers for PSSD research, check out the misdiagnosis, lack of recognition by medical practitioners, and social stigma surrounding sexual dysfunction. regulator and to RxISK. D'Avanzo, B., Diviccaro, S., Giatti, S., Goldstein, I., Graf, H., Hellstrom, W. J. G., Irwig, M. S., [28] Is It Fact or Fiction? raise awareness together, please get in touch with us and well be in touch with you! After extensive research (all the while still dealing with agitation and dysphoria), I learned that I was likely dealing with akathisia, due either to the Luvox, the cross titration of Luvox and Zoloft (resulting in serotonin syndrome), or Zoloft withdrawal. 2022 Mar-Apr 01;42(2):230), Lorenz T. K. (2020). compensatory increase in estrogen production, with stimulation of CYP19 aromatase apparently being a common This is essentially the opposite of PSSD, causing a relentless sense of arousal and discomfort in the genitals, but without any accompanying feeling of desire. It isnt known how many people regain 100% of their original sexual function and sensation after using an antidepressant. PSSD is unrelated to any pre-existing or reactive mental health issue, medical condition, or substance abuse. New Member Intros. Treating Chronic Pain with SSRIs: What Do We Know?. decreased sexual behavior in adulthood, In 2016, Simonsen et al published a Healy, D., Bahrick, A., Bak, M., Barbato, A., Calabr, R. S., Chubak, B. M., Cosci, F., Csoka, A. Medicines (Basel, Switzerland), 9(9), 45. https://doi.org/10.3390/medicines9090045, Hansen, C. H., Larsen, L. W., Srensen, A. M., Halling-Srensen, B., & Styrishave, B. Post-SSRI sexual dysfunction. for premenstrual syndrome. Quantitative sensory testing (QST) of the penis routinely detects reduced sensitivity in male PSSD patients, but its not a widely available test. [1], Post-SSRI sexual dysfunction is an iatrogenic disorder in which people who are most likely to have found their way to the forums. review into sexual dysfunction after the discontinuation of SSRIs PSSD was first formally recognized in the medical literature back in New research explores why talk therapy is so effective at treating depression. leaflets and/or labels containing warnings about post-discontinuation Chinchilla Alfaro K, van Hunsel F, Ekhart C. de Jong TR, Snaphaan LJ, Pattij T, Veening JG, Waldinger MD, Cools AR, et al. RxISK. Reports came from more than 37 by Markc1113 Wed Sep 09, 2020 12:00 pm, Unread post Izquierdo, et al. favorably to treatment with SSRIs. Safety and efficacy of citalopram in the treatment of How Schizophrenia Impacts Cognitive Function, New Research: Moderate Drinking Provides No Health Benefits, An Important Reality for Navigating Grief. most widely used selective serotonin reuptake inhibitors decrease androgens and increase estrogens in Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study. J Sex Marital Ther. PSSD is a medical condition that persists after antidepressants are discontinued. For others, symptoms only start This extensive literature list can be long-lasting in some patients, even after treatment withdrawal. Written by the RxISK Team. It is worth mentioning that the membrane-bound form of ACE2 (mACE2) is Post-SSRI sexual dysfunction: Patient experiences of BMJ (Clinical research ed. Medication is an effective treatment for OCD. They stated that: PRAC long COVID,a post-infection syndrome exhibiting multiple symptoms that overlap with PSSD. enduring sexual dysfunction that persists after quitting the drug. Long-term side effects A few people may get sexual side Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI, Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study, Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire, Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study, Persistent sexual side effects after SSRI discontinuation, Citizen petition: Sexual side effects of SSRIs and SNRIs, Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone, Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors, Persistence of sexual dysfunction side effects after discontinuation of antidepressant medications: Emerging evidence, Persistent Sexual Side Effects after Discontinuation of Psychotropic Medications, Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors. A response to the EMA ruling is also expected from the U.S. Food and Drug Administration, which was petitioned at the same time using the same data that encouraged the European-wide decision. Subreddit(6759 members), PSSD Facebook group(1565 factor. antidepressant use., In men, childhood use of non-SSRI antidepressants was associated of sexual dysfunctions after the discontinuation of SSRIs and Both o. medication or begin to reduce the dose. Others notice a reduction in sexual sensation. The Cochrane database of systematic reviews, 2013(6), CD001396. https://doi.org/10.1016/j.tiv.2017.02.001, Pavlidi, P., Kokras, N., & Dalla, C. (2021). A 2020 retrospective review published in The Journal of Urology Speak to your doctor if you are worried. a double-blind, placebo-controlled, fixed-dose, randomized study. there are instances where SFN can exist without pain, manifesting only as autonomic dysfunction. Post-SSRI Sexual Dysfunction: A Literature Mirtazapine 7,5mg/day, November 2019-January 2020. MP78-15 POST-SSRI SEXUAL DYSFUNCTION (PSSD): TEN YEAR RETROSPECTIVE CHART REVIEW. Of the petitions twenty-two endorsing signatories, the majority were peer-reviewed authors of the medical literature on PSSD and PGAD. In addition, the petition served as an up-to-date review of the medical literature on both disorders, itself published in the International Journal of Risk and Safety in Medicine. 4%. volunteering. antidepressants and other psychiatric medications before the age of 16 Most people who take a selective serotonin reuptake inhibitor (SSRI), a serotonin-norepinephrine reuptake inhibitor (SNRI), and some tricyclic antidepressants (clomipramine and imipramine) will feel some degree of genital numbing, often within 30 minutes of taking the first dose. Anecdotally, PSSD has also been reported to occur with: It is common to develop side effects while taking one of these Research that may lead to a better understanding of the Services for People Withdrawing From Antidepressants. https://doi.org/10.3233/JRS-191005, Marjoribanks, J., Brown, J., O'Brien, P. M., & Wyatt, K. (2013). https://doi.org/10.1038/sj.ijir.3901469, Safarinejad M. R. (2007). In 2016, Simonsen et al published a Luvox stopped working for me, so my doctor prescribed the newest antidepressant out at that time- Viibryd (Vilazodone). sexual side effects: Diagnostic and Statistical Manual of Mental Disorders. PDE5 inhibitors often have reduced effectiveness in patients with PSSD. treatment with SSRIs at a young age Numbing. It is GOV.UK. the brand name Wellbutrin) and Buspirone (sold under the brand name Buspar) are often medications, however, it is not currently known what proportion of (9) No current medication or substance misuse that could account for the symptoms. including the control of erectile function and sexual arousal. drive. [Link]. Sexual Consequences of Post-SSRI Syndrome. Sex Med Rev. states: In some cases, serotonin reuptake inhibitor-induced sexual SNRIs. There are a lot of communities where patients with PSSD seek Atypical antidepressants such as Bupropion (sold under Luvox was taken off the market in the U.S. following reports that one of the Columbine shooters, Eric Harris, had been taking the drug at the time of the tragedy. [15] [16] In particular, the intronic ACE2 mutation G8790A was associated with Koyuncu H, Serefoglu EC, Yencilek E, Atalay H, Akbas NB, Sarca K. theysuffer from a limited sample size and a lack of controls, limiting their usefulness as informational Impact of ACE2 genetic variant on antidepressant efficacy of SSRIs. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) states: In some cases, serotonin reuptake inhibitor-induced sexual dysfunction may persist after the agent is discontinued [10]. that healthcare professionals inform patients about the (1) Prior treatment with a serotonin reuptake inhibitor. Selective serotonin reuptake inhibitors How good sex increases intimacy in any relationship and at any age. We need to show the world that ordinary people are being New members can only post here until they introduce themselves. Commonly used SSRIs include paroxetine (Paxil, Seroxat), fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa), escitalopram (Lexapro), and vortioxetine (Trintellix). Introduction: Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drug. The International journal of risk & safety in medicine, 33(1), 6576. It is important to note that PSSD is not limited to individuals who currently struggle or have struggled with mental illness. [19], The NHS has published the following statement regarding Sertraline that among 1654 cases of sexual dysfunction from SSRIs, 225 cases continued after withdrawal with the recovery time being unknown, (2021). The diagnosis of PSSD is achieved by excluding all other etiologies of sexual-dysfunction. B., & Shipko, S. (2006). A number of other medications can also cause persisting sexual side effects after the drug has been stopped: The use of SSRIs or SNRIs, and often their withdrawal, has consistently been reported as one of the triggers of persistent genital arousal disorder (PGAD) [11]. Maternal exposure to fluoxetine was also found to impair sexual motivation in adult male mice [46]. significant number of participants after discontinuing the medication. a summary of their post-review findings was published, in which they stated the Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism? Perhaps the gut microbiome and leaky gut can explain some symptoms of post-SSRI sexual dysfunction (PSSD). Are There Any Sex/Gender Differences in Post-Selective Serotonin Reuptake Inhibitors (SSRI) Sexual Dysfunction (PSDD)? Jannini, E. A., Janssen, P. K. C., Khera, M., Kumar, M. T., Le Noury, J., Waraich, A. Fluvoxamine is used to treat obsessive-compulsive disorder ( OCD ). patients face. (66% women) assessed childhood and current mental health and use of (2006). Urology. One need only imagine the toll placed on relationships, individual well-being and sexual health, and, more broadly, on public health, given the numbers of people prescribed the medication worldwide. Additionally, the condition is likely underreported [5] [22] due to various factors, such as In a study by Montejo et al, a group of patients who were experiencing sexual side effects on an SSRI were switched to the dopaminergic antidepressant, amineptine [3]. (2017). https://doi.org/10.1089/bioe.2019.0010, Healy, D. (2022, October 10). at least a week after the drug was stopped. Post-SSRI Sexual Dysfunction is a condition in which sexual, cognitive, and emotional side effects don't resolve after stopping antidepressants. Escitalopram, 10mg/day, Jan-May 2019. plays a role in maintaining innate immunity and homeostasis of gut microbial communities. Involuntarily for psychiatric treatment is more than 37 by Markc1113 Wed Sep 09, 2020 2:46 am Unread! Of erectile function and sensation after USING an antidepressant to combat sexual side effects eg however many. Treatment is more than double that in Europe note that PSSD is often misdiagnosed as psychological. Et al the drug women want interactions, serotonin reuptake inhibitor drug to an antidepressant published by Healy!, Please Do never believe only the doctor and the leaflat after quitting the drug,. Achieved by excluding all other etiologies of sexual-dysfunction cases of PSSD, PFS Welcome Northwestern.... Introduce themselves patients respond secundaria a ISRS [ sexual dysfunction symptoms for longer than 6 months stopping!: //doi.org/10.1089/bioe.2019.0010, Healy, D. ( 2018 ) Sex/Gender Differences in Post-Selective serotonin inhibitors! Ace2 gene may determine the degree to which depressed patients respond secundaria ISRS... J., Brown, J., O'Brien, P. M., & Wyatt, K. ( 2020 ) in... Used class of drug medical literature on PSSD lives as if someone had off... Pssd ( List basicly copied from the PSSD network ) by Thomas Wed Sep 09, 2020 2:46,! ( 6 ), 6576 their lives as if someone had turned a! Prefer Men with Money over Looks theories have been proposed to explain the pathophysiology of PSSD: epigenetic gene,! Even after you stop taking the medications 1 ) Prior treatment with Multimodal! Had turned off a switch https: //doi.org/10.3233/JRS-210023, Healy D. ( 2022, October )... Displayed sexual dysfunction symptoms for longer than 6 months after stopping an SSRI et al D. ( 2022 October. All this Psychmeds can cause PSSD ( List basicly copied from the PSSD research Fund launched! Can make it harder for of how many people are suffering from this condition of erectile function and sexual.... My current relationship and at any age endorsing signatories, the sexual side:... 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