Use Caution/Monitor. Minor/Significance Unknown. oxaprozin and tolvaptan both increase serum potassium. Use Caution/Monitor. Long term (>1 wk) NSAID use. This is a decision you and your doctor will make. Increased risk of GI ulceration. Monitor Closely (3)sacubitril/valsartan, oxaprozin. Use Caution/Monitor. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Daypro Descriptions Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Copyright(c) 2023 First Databank, Inc. Minor/Significance Unknown. defibrotide increases effects of oxaprozin by P-glycoprotein (MDR1) efflux transporter. ketoprofen and oxaprozin both increase serum potassium. oxaprozin and reteplase both increase anticoagulation. oxaprozin increases and dopexamine decreases serum potassium. Meloxicam is only available on prescription and ibuprofen is available over the counter as well as on prescription. Monitor Closely (3)valsartan, oxaprozin. Use Caution/Monitor.Serious - Use Alternative (1)oxaprozin, ketorolac intranasal. This effect can occur without warning symptoms at any time while taking this drug. Effect of interaction is not clear, use caution. Monitor Closely (1)oxaprozin, betrixaban. Effect of interaction is not clear, use caution. oxaprozin and epoprostenol both increase anticoagulation. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. pindolol and oxaprozin both increase serum potassium. Minor/Significance Unknown. Use Caution/Monitor.lornoxicam and oxaprozin both increase serum potassium. nabumetone and oxaprozin both increase anticoagulation. Increased risk of upper GI bleeding. Use Caution/Monitor. This drug is available at a higher level co-pay. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Modify Therapy/Monitor Closely. Use Caution/Monitor.aspirin rectal and oxaprozin both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. unspecified interaction mechanism. pharmacodynamic antagonism. Use Caution/Monitor. oxaprozin increases levels of paromomycin by decreasing renal clearance. oxaprozin increases and epinephrine racemic decreases serum potassium. clopidogrel, oxaprozin. oxaprozin, ramipril. Use Caution/Monitor. oxaprozin and potassium chloride both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. acebutolol and oxaprozin both increase serum potassium. Use Caution/Monitor. Increased risk of GI ulceration. SSRIs inhib. . Modify Therapy/Monitor Closely. Increased risk of upper GI bleeding. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. Use Caution/Monitor.oxaprozin decreases effects of bisoprolol by pharmacodynamic antagonism. bendroflumethiazide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Promptly evaluate any signs or symptoms of blood loss. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity. Minor/Significance Unknown. Monitor Closely (2)oxaprozin and sulfasalazine both increase anticoagulation. This medication may harm an unborn baby and cause problems with normal labor/delivery. oxaprozin and danshen both increase anticoagulation. Modify Therapy/Monitor Closely. Monitor Closely (2)oxaprozin and salicylates (non-asa) both increase anticoagulation. oxaprozin, methylprednisolone. Either increases toxicity of the other by Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Use sunscreen and wear protective clothing when outdoors. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Concomitant use may increase risk of bleeding. Modify Therapy/Monitor Closely. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. sotalol and oxaprozin both increase serum potassium. oxaprozin decreases effects of feverfew by pharmacodynamic antagonism. Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis in adults. Use Caution/Monitor. Use Caution/Monitor.Minor (1)oxaprozin will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. oxaprozin, zanubrutinib. Modify Therapy/Monitor Closely. metoprolol and oxaprozin both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. It is an NSAID (Non-Steroidal Anti-Inflammatory Drug). Minor (1)creatine, oxaprozin. Therapeutic duplication, ibuprofen IV will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. oxaprozin and sparsentan both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Use Caution/Monitor. oxaprozin increases levels of lithium by decreasing renal clearance. Talk to your doctor if you are using marijuana (cannabis).This medicine may cause stomach bleeding. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. oxaprozin, ciprofloxacin. The manufacturer recommends that adults should not take more than 1,800 milligrams per day or 26 milligrams per kilogram per day, whichever is lower. Use Caution/Monitor. Minor/Significance Unknown. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. indapamide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Defibrotide may enhance effects of platelet inhibitors. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)oxaprozin increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Monitor Closely (1)oxaprozin, hydrocortisone. oxaprozin will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Monitor Closely (2)temocillin, oxaprozin. celecoxib will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. STORAGE: Store at room temperature away from light and moisture. oxaprozin decreases effects of prazosin by pharmacodynamic antagonism. serotonin uptake by platelets. Either increases levels of the other by decreasing renal clearance. oxaprozin and potassium acid phosphate both increase serum potassium. ofloxacin, oxaprozin. Monitor Closely (1)oxaprozin decreases effects of prazosin by pharmacodynamic antagonism. green tea, oxaprozin. Minor/Significance Unknown. SSRIs inhib. Therapeutic duplicationibuprofen and oxaprozin both increase serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Increased risk of upper GI bleeding. Monitor Closely (1)ticagrelor, oxaprozin. Use Caution/Monitor. Use Caution/Monitor. oxaprozin, triamcinolone acetonide injectable suspension. Monitor Closely (1)travoprost ophthalmic, oxaprozin. Each drug may increase the photosensitizing effect of the other. Use Caution/Monitor.oxaprozin and sulfasalazine both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. oxaprozin increases and salmeterol decreases serum potassium. generic drugs or brand names) are also considered. oxaprozin increases and vitamin K1 (phytonadione) decreases anticoagulation. People with chronic neuropathic pain and fibromyalgia reported small short-term improvements in pain and function with certain anticonvulsants and moderate short-term improvement with certain antidepressants. fondaparinux and oxaprozin both increase anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. potassium iodide and oxaprozin both increase serum potassium. oxaprozin decreases effects of doxazosin by pharmacodynamic antagonism. oxaprozin and dong quai both increase anticoagulation. Use Caution/Monitor. Monitor Closely (1)oxaprozin increases and gentamicin decreases serum potassium. Use Caution/Monitor. SSRIs inhib. NSAIDs decrease prostaglandin synthesis. Modify Therapy/Monitor Closely.Minor (2)triamterene, oxaprozin. Use Caution/Monitor. SSRIs inhib. Use Caution/Monitor. Use Caution/Monitor. lornoxicam and oxaprozin both increase anticoagulation. Minor/Significance Unknown. oxaprozin and sulindac both increase anticoagulation. fenoprofen and oxaprozin both increase anticoagulation. Use Caution/Monitor. methyclothiazide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. acemetacin will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. To view formulary information first create a list of plans. Monitor Closely (1)oxaprozin decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Either increases toxicity of the other by Other (see comment). ticarcillin, oxaprozin. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. mefenamic acid and oxaprozin both increase serum potassium. Interaction mainly occurs in preterm infants. 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