Patients and physicians should be aware of the potential for additive effects. The herb was brought from the eastern Mediterranean by way of the Silk Road, which stretches from China across central Asia. View abstract. Rhubarb is widely used in traditional Chinese medicine. Chen, X. and Ran, R. [Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis]. They stir fry rhubarb root with wine to reduce the laxative effect when it is used for diseases other than constipation. Its manufacturers claim that it can help people experiencing menopause. Mao QL. 2005;3(3):195-198. 1993;13(2):71-3, 67. Researchers found a clear decrease in the number hot flashes and symptoms in women who had taken ERr 731. I did not want to do HRT so started taking this. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. August 7, 2022. Yang, N., Liu, X., and Lin, Q. In 1731, a rhubarb commission was set up at the Mongolian border to import the best possible root at a fixed price. All rights reserved. Chen Q, Han G, Zhuang X, and et al. and check out those references. A. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. Further information about Estroven is available here. Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. Preliminary data suggest rhubarb may have added benefits for patients with sepsis when used with the protease inhibitor ulinastatin(34), or may help treat recurrent aphthous stomatitis(25). Rhubarb contains chemicals that might help . Medically reviewed by Drugs.com. While some of these side effects like discolored urine are harmless, some others are mild. 1996;11(1):186-190. Menopause can cause symptoms such as hot flashes and night sweats, which make sleep more difficult. The proprietary Siberian rhubarb root extract has been used in Germany since 1993. 1993;13(5):286-8, 261-2. In Traditional Chinese Medicine (TCM), the rhizome and root are use to treat gastrointestinal and liver diseases. The anthraquinone derivatives of rhubarb have been used as antifungal38, 39 and molluscicidal40 agents. ERr 731 is a standardized extract of Siberian rhubarb root, a plant-derived, nonhormonal therapy designed to alleviate menopausal symptoms, including hot flashes. MNT is the registered trade mark of Healthline Media. Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. Silica is a well-known ingredient that is going to have very nice overall effects on your hair, nails, and entire body. Diarrhea or constipation: Rhubarb can make diarrhea or constipation worse, depending on the preparation used. Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the General (Jiang Jun) in Chinese medical herb. The entire process of menopause lasts about 7 years for most people. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others. View abstract. Amberen has an average customer rating of 1.9 out of a possible 5 stars on Trustpilot. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Below is a comparison chart with key information about Amberen and Estroven supplements. Estrovera reduces the severity of menopausal symptoms. People may use menopause supplements, such as black cohosh and St. John's wort, to ease symptoms. Rhubarb is derived from several Rheum species. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. Is rhubarb anti-inflammatory? Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Liver problems: Rhubarb can make liver function worse in people who already have liver problems. Similarly to lipid-lowering properties of rhapontic rhubarb, also R. rhabarbarum showed a cardioprotective potential. Zheng, F. [Effect of Rheum officinal on the proliferation of renal tubular cells in vitro]. At the same time, the reviews are quite ambiguous this is also something worth accounting for. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Rhubarb is a laxative. View abstract. Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases, vitamins, herbs, dietary supplements a-z list. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(11):655-7, 643. Rheum rhaponticum is a robust perennial herbaceous plant growing from a woody rhizome. A difference in response to treatment was evident within the first four weeks of treatment with ERr 731 compared with a placebo. Anti-proliferative effects of estrogen receptor-modulating compounds isolated from, Effect of the water extract and ethanol extract from traditional Chinese medicines. Amberen and Estroven are two supplements for people who are going through menopause. I couldnt sleep, I was cranky, anxious, depressed and I was breaking out in hot flashes and night sweats constantly. In food, rhubarb stems are eaten in pie and other recipes. Wang, H. H. Antitrichomonal action of emodin in mice. [Clinical evaluation of crude rhubarb powder and cimetidine in upper gastrointestinal bleeding]. 1993;18(11):679-81, 703. From diagnosis to treatment, our experts provide the care and support you need, when you need it. However, sound clinical evidence for its use is lacking. Bi, Z. Q. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. These products include Stress Relief & Energy Boost, Weight Management, and Sleep Cool. Really! Once you have taken the picture, save the image as a JPG, TIF, or PDF file. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you already have kidney disease, don't risk making it worse by taking rhubarb. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation(41). 7. Stimulant laxatives speed up the bowels. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. 2 Improvements were . [Nitrogen balance in uremic patients treated with rhubarb retention enema]. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. *All individuals are unique. Do not take rhubarb if you are taking a medication that can harm the liver. Key takeaways: Gabapentin (Neurontin) can interact with medications and substances that make you sleepy. This information is not specific medical advice and does not replace information you receive from your health care provider. This menopause relief supplement is recommendable since scientific data back it. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation . We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials.". The root and underground stem (rhizome) are used to make medicine. Matsuda, H., Morikawa, T., Toguchida, I., Park, J. Y., Harima, S., and Yoshikawa, M. Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. They dont seem to be thoroughly supported by the ingredients and the working process of the product. Lipid profiles were improved in the two experimental arms.22, Treating hypercholesterolemia in men with rhubarb stalk fiber for 4 weeks lowered serum total cholesterol and low-density lipoproteins (LDL), while high-density lipoproteins remained unchanged.26 In 103 patients with atherosclerosis randomized to receive the extract for 6 months, rhubarb extract improved the lipid profile in patients with chronic renal failure (CRF) compared with control.25 Individuals taking rhubarb reported decreased LDL compared with those taking placebo and compared with the pretreatment levels.27, The North American Menopause Society position statement for nonhormonal management of menopause-associated vasomotor symptoms (2015) states that although beneficial effects in overall symptoms have been reported with a commercial proprietary rhubarb extract preparation, more data are needed on both safety and efficacy of Siberian rhubarb (Rheum rhaponticum) for use in menopausal vasomotor symptoms (Level II).58, Large, randomized clinical trials are lacking. Positive reviews mention that the supplement reduced menopause symptoms. The dry extract from the roots of rhapontic rhubarb (Rheum rhaponticum) belongs to the group of phytopharmaceuticals. Hence, rhubarb has been used to treat patients with renal failure. Learn more here. Cultivating red-stalked rhubarb plants is an important source of raw materials for producing health-promoting foods. However, one of the products main ingredients is black cohosh. Learn about the effectiveness, side effects, and. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Note: Results may vary about any product effectiveness. Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Yarnell E. Rhubarb and diabetic nephropathy. Uterine contractions. View abstract. View abstract. In a small study of lung cancer patients, a rhubarb extract reduced radiation-induced lung toxicity and increased pulmonary function . ERr 731 has been in use in Germany and other areas of Europe since 1993. . Topical therapy with rhubarb navel plasters in patients with chronic constipation: Results from a prospective randomized multicenter study. The following are common questions and answers about Amberen and Estroven: Amberen and Estroven are available to purchase from large retailers, including: Neither Amberen nor Estroven has Food and Drug Administration (FDA) approval. Negative reviews mention no positive benefits and several adverse side effects. 4) Treats cold sores. Beck S, Richardson A, et al. Taking rhubarb along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body. Zhang, JH, Yao, XD, Song, Y, and et al. A., and Beaulieu, A. D. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. J.Tradit Chin Med 1981;3:211-213. Fairbairn JW. . In most cases, rhubarb root side effects are associated with large dosages, especially those with longer durations. Li, C., Zhou, J., Gui, P., and He, X. HRT caused terrible side effects after about 3 months, and the accompaniments worked for a few months at best. View abstract. As its constituents belong to the class of natural hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. Use of this Web site does not create an expressed or implied physician-patient relationship. Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Nutrition Research 1998;18(5):893-903. How to handle headaches, night sweats, and more. Stop using this product and call your doctor at once if you have signs of liver problems, such as: nausea, loss of appetite, upper stomach pain; itching, tired feeling; dark urine, clay-colored stools; or. Menopause and insomnia: What is the link? Zhongguo Zhong.Yao Za Zhi. J Am Coll.Nutr 1997;16(6):600-604. View abstract. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. Estroven claims that this ingredient activates estrogen receptors and reduces menopausal symptoms. Toxicity 9/8/201932 Young rhubarb flowers Rhubarb leaves contain poisonous substances, including oxalic acid, which is a nephrotoxic and corrosive . View abstract. Lee, H. Z. Papke, and O. Zierau. Rhapontic Rhubarb Root Extract has been trusted by physicians for over 20 years to relieve menopause symptoms, given its safety and efficacy profile. View abstract. Pregnancy and breast-feeding: Rhubarb is POSSIBLY UNSAFE when used in amounts greater than those found in foods. It started working within 6 weeks and to date, I have never felt better. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. I was in full swing menopause and I was pretty miserable. Rhubarb is a type of laxative called a stimulant laxative. Rhubarb is considered to be a stimulant laxative. For treatment of cold sores: a cream containing 23 mg/gram each of rhubarb extract and sage extract applied every 2 to 4 hours while awake, with treatment starting within one day of symptom appearance and continuing for 10 to 14 days. Higher-strength products had a greater effect than lower-strength products in the studies. Zhu, Y. Imagine my surprise when it conquered all of them?! Zhou, Y, Huang, Z, Huang, T, and et al. 2005 - 2023 WebMD LLC, an Internet Brands company. Rhubarb has been studied for the management of GI and renal function disorders, and for the treatment of hyperlipidemia, cancer, and acute ischemic stroke. But in the wake of studies that suggest HRT may increase the risk of heart diseaseheart disease and breast cancer, they are currently recommended only for short-term use. View abstract. Kidney stones: Rhubarb contains a chemical that the body can convert into kidney stones. 1980;90(8):718-724. Harima, S., Matsuda, H., and Kubo, M. Study of various rhubarbs regarding the cathartic effect and endotoxin- induced disseminated intravascular coagulation. Please read the full product reviews disclaimer. Zhong.Xi.Yi.Jie.He.Xue.Bao. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). View abstract. Clinical study on rhubarb extract tablet in treating simple obesity. Rhaponticum. The root has been used traditionally to support a . Amberen and Estroven are supplements that claim to reduce menopause symptoms but contain different ingredients. However, a person should speak with a doctor before taking either product. It claims to have been clinically demonstrated to relieve menopausal symptoms like hot flashes, sleep disturbances, irritability, anxiety, mood problems, exhaustion, and vaginal dryness. However, the molecular basis of its clinical effectiveness remains obscure. [The efficacy and tolerability of Pyralvex solution and Pyralvex Gel in the treatment of gingivitis. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Der Freie Zahnarzt 1997;9:76-80. Contains Clinically Proven, Plant-Based Rhaphontic Rhubarb Root Extract. 3 E Evergreen Road #1193, New City, NY 10956 Other animal studies suggest potential for liver toxicity at high doses and with long-term use, in part due to anthraquinone compounds such as rhein and emodin as well as tannins(40). A: Menopause supplements like Estrovera may interact with patients with severe heart disease and high blood pressure. Laxatives can decrease how much medicine your body absorbs. Wang, Y. J., Xu, L., and Cheng, X. X. Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. Estroven does not mention side effects on their website. You can take these products together and they are available at health food stores and online. Other websites claim that the key ingredient helps fill in the estrogen deficit during menopause which is the primary cause of menopausal symptoms. Interactions 9/8/201931 Interaction with cardiac glycosides (digoxin) and a reduction in the absorption of orally administered drugs have been noted when rhubarb is taken in large quantities. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. Safety and efficacy of NT, an herbal supplement, in treating human obesity. supports restful sleep, boosts energy, helps to manage daily stress, mood and irritability, promotes joint and muscular comfort, supports View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Amberen claims that its product has no adverse side effects. Lets take a look at one such menopause supplement that is currently very popular and determine if it is worth purchasing. Int J Obes (Lond). Am J Chin Med 2005;33(6):839-850. Dr Oz: Ashwagandha Supplements - Ashwagandha Supplement: Take 500 mg twice a day. Gut 2000;46:651-5. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. extract significantly improved symptoms as compared to placebo. In fact, a supplement that contained rhubarb has been linked to one report of kidney failure. Crude rhubarb extract 9 g powder was given daily to patients with sepsis. A few reactions, primarily GI effects, have been reported in clinical trials. Xin SF, Zhuang H, Mo QY, and et al. Taking rhubarb with medications that can harm the kidneys might increase the chance of kidney damage. Negative reviews mention adverse side effects from the product. Another main ingredient of Estroven is soy isoflavones. Plant-Based Extract, Vegan, Drug, Soy, Hormone and Gluten Free. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Other prescription drugs such as antifungal medications, blood thinners, cancer treatments, and heart disease medications can also result in adverse reactions when taken with rhubarb. German doctors have been using Estrovera to help their menopausal patients for 20 years. * Multiple clinical trials demonstrate effectiveness and safety of this ingredient, including a two-year-long study. Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others. The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. Sun, D. A. Rhubarb is extensively used in traditional Chinese medicine. Native to Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides) is a perennial herb that is commonly called maral root. Additional studies to confirm safety and efficacy are needed. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. According to study this is something that plays an important role in your muscle contractions[4] and for the enzyme operations. Other studies suggest it may improve feeding tolerance and relieve gastrointestinal dysfunction in critically ill patients(23) or help prevent procedure-related pancreatitis and hyperamylasemia in high-risk patients(24). Therefore there is much interest in finding safe, alternative treatments for hot flashes and other symptoms caused by menopause. See additional information. It may also reduce excess blood levels of pancreatic enzymes and pancreatitis events caused by some procedures. Rhubarb - Dietary supplement use in human (PubMed) Synonyms/sources: Chinese rhubarb rhizome extract; Err 731; Err 731 siberian rhubarb (rheum rhaponticum l.) extract; Organic rhubarb; Organic turkish rhubarb; Rhapontic rhubarb (rheum rhaponticum l.) root extract; Rhapontic rhubarb root extract; Rheum palmatum, powder; Rheum rhaponticum root . WHAT IS RHUBARB ROOT? Avoid dosages higher than those found in food because safety and efficacy are unproven. 4-21-2006;105(1-2):118-124. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. Odenthal, K. P. and Ziegler, D. In vitro effects of anthraquinones on rat intestine and uterus. Furthermore deoxyrhaponticin, chrosophanic acid, oxalic acid and tanning . It also has additional products that target specific symptoms. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Menopause is different from the menopausal transition stage known as perimenopause. Adjuvant treatment with crude rhubarb for patients with acute organophosphorus pesticide poisoning: A meta-analysis of randomized controlled trials. As a result, we recommend you get medical advice before taking it. Animal studies suggest the potential for liver toxicity at high doses and with long-term use. Diarrhea may be accompanied by abdominal cramping, bloating or appetite loss. Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis. Biological assay and its relation to chemical structure. Rhapontic Rhubarb Root extract, Microcrystalline Cellulose, Stearic Acid, Silica, and Sodium. Several scholarly articles can be found online that describe the efficacy and safety profile of rhubarb extracts in the treatment of menopausal symptoms such as hot flashes, sweating, sleep disturbances, and mood swings.

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