Ali, M. and Thomson, M. Consumption of a garlic clove a day could be beneficial in preventing thrombosis. View abstract. Clin Pharmacol Ther 2003;74:170-7.. View abstract. Gu Y, Zhang S, Wang J, et al. Effect of garlic on blood pressure: A systematic review and meta-analysis. View abstract. Dtsch Apoth Ztg 1989;129(suppl 15):1-25. Common side effects of topically applied clove may include: erection problems; trouble having an orgasm (delayed ejaculation); itching, rash; mild skin irritation; or sore gums, mouth irritation, bleeding or swollen gums, or tooth changes after using clove inside the mouth. Lash, J. P., Cardoso, L. R., Mesler, P. M., Walczak, D. A., and Pollak, R. The effect of garlic on hypercholesterolemia in renal transplant patients. View abstract. Ceska.Slov.Farm. Alliaceous migraines.Headachevol. This can help prevent some indigestion and gas.. A., Sereda, E. V., Borodina, L. I., and Studenikin, M. I. View abstract. Garlic odor has been found to linger in the mouth long after brushing. J Med Assoc Thai 2003;86:750-7. 2010;45(4):356-362. Davis, S. R., Perrie, R., and Apitz-Castro, R. The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum). Int J Dermatol. Allium vegetables and risk of prostate cancer: a population-based study. Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. McHugh CP. Takeuchi, S., Matsuzaki, Y., Ikenaga, S., Nishikawa, Y., Kimura, K., Nakano, H., and Sawamura, D. Garlic-induced irritant contact dermatitis mimicking nail psoriasis. 2012;110(5):476-481. Am J Hypertens. Common side effects (especially when eating raw garlic) may include: unpleasant breath or body odor; heartburn, burning in your mouth or throat; nausea, Bruynzeel DP. Phytother.Res. The Cleveland Clinic also identified garlic as a potential trigger for headaches. [Postprandial lipemia under treatment with Allium sativum. A 30-year study of 125,000 people found that garlic consumption was associated with a reduction in gastric cancer risk. Black or bloody stool. Clin Nutr. View abstract. To avoid gastrointestinal upset, you should gradually introduce or increase the amount of garlic you consume. Kiesewetter, H., Jung, F., Pindur, G., Jung, E. M., Mrowietz, C., and Wenzel, E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Effect of garlic powder tablets on blood lipids and blood pressure: a six month placebo controlled double blind study. Phytomedicine. Garlic is widely recognized for its ability to fight bacteria, viruses, fungi, and even parasites. J Nutr. Nutrients 2022;14(3):405. Some specific enzymes in garlic may lead to this irritation. Pharmaceutical Biology (Netherlands) 2005;43:209-218. Garlic powder and plasma lipids and lipoproteins, a multicenter, randomized, placebo-controlled trial. Vorberg G, Schneider B. Prostaglandins Leukot Essent Fatty Acids 2000;62:55-73. Feldberg, R. S., Chang, S. C., Kotik, A. N., Nadler, M., Neuwirth, Z., Sundstrom, D. C., and Thompson, N. H. In vitro mechanism of inhibition of bacterial cell growth by allicin. View abstract. Anon. 10-3-2003;73(20):2543-2556. Accessed October 23, 2020. View abstract. View abstract. Gwilt PR, Lear CL, Tempero MA, et al. 2004;94(1):155-158. View abstract. View abstract. Garlic has been used for blood vessel disease ( atherosclerosis) and high blood pressure (hypertension). View abstract. Nutr Metab Cardiovascular Dis 1996;6:21-31. J Med Food 2005;8(3):319-326. October 2007. https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2007/13167a-eng.php. Expertise: Weight Loss Nutrition, Female Wellbeing, & Sports Nutrition, Alexandra Dusenberry is a registered dietitian nutritionist and a certified personal trainer based in San Diego, California. Hansson LE, Nyren O, and Bergstrom R. Diet and risk of gastric cancer: a population-based case-control study in Sweden. Intake of fat, meat, and fiber in relation to risk of colon cancer in men. View abstract. Therefore, people who suffer from frequent headaches may want to avoid using garlic. Sato T, Miyata G. The Nutraceutical Benefit, Part IV: Garlic. Ter.Arkh. Mostafa MG, Mima T, Ohnishi ST, Mori K. S-allylcysteine ameliorates doxorubicin toxicity in the heart and liver in mice. View abstract. Br J Cancer 2022;126(12):1755-1764. Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. 2003;75(3):53-56. Evans V. Herbs and the brain: friend or foe? 1999;43(6):837-839. Lembo, G., Balato, N., Patruno, C., Auricchio, L., and Ayala, F. Allergic contact dermatitis due to garlic (Allium sativum). Health Canada. Some of the side effects of garlic supplements are: Gastric derangement: irritation in the stomach, vomiting and nausea, diarrhea and bloating of the abdomen. 2011;28(3):589-598. Kiesewetter H, Jung F, Jung EM, et al. This could decrease the effects of some medications used for HIV/AIDS. 3-21-2012;104(6):488-492. View abstract. Excess garlic consumption may affect the liver. Garlic might decrease how quickly the liver breaks down tacrolimus. Recent Pat Cardiovasc Drug Discov 2013;8(1):56-66. Sheela, C. G. and Augusti, K. T. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Hurley, M. N., Forrester, D. L., and Smyth, A. R. Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis. Pak J Pharm Sci 2013;26(5):859-63. Vopr.Onkol. View abstract. Helicobacter. J Int Soc Sports Nutr 2013;10(1):22. Eur.J Obstet.Gynecol.Reprod.Biol. Herbal Medicine Expanded Commission E Monographs. View abstract. 2020. Bulb dermatitis. Arzneimittelforschung 1993;43:119-22. View abstract. Relationship between consumption of raw garlic and handgrip strength in a large-scale adult population. Phytomedicine 1997;4(1):79-83. Public Health Nutr. Garlic supplements may cause blood pressure to drop too low. View abstract. View abstract. Is It (Finally) Time to Stop Calling COVID a Pandemic? Shaikh SA, Tischer S, Choi EK, Fontana RJ. in an ovariectomized rat model of osteoporosis. Ledezma E, Lopez JC, Marin P, et al. Sobenin, I. View abstract. Arch Dermatol 1950;61:111. View abstract. Carcinogenesis 1996;17:477-84. Wang BH, Zuzel KA, Rahman K, Billington D. Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. J Cardiovasc Pharmacol 1998;31:904-8. View abstract. Arch Intern Med 2001;161:813-24. 2004;50(1):81-85. View abstract. Arch.Dermatol.Forsch 8-15-1973;247(2):117-124. View abstract. View abstract. Garlic might lower blood pressure. View abstract. Borrelli, Francesca et al. View abstract. Int J Dermatol. Am J Epidemiol. Chin Med J (Engl.) Kenzelmann R, Kade F. Limitation of the deterioration of lipid parameters by a standardized garlic-ginkgo combination product. View abstract. If you consume raw garlic, you also run the risk of the nasty garlic smell seeping through your pores. Wohlrab, J., Wohlrab, D., and Marsch, W. C. Acute effect of a dried ethanol-water extract of garlic on the microhaemovascular system of the skin. 1996;24(3):811-814. Gaddoni G, Selvi M, Resta F, and et al. 2012;33(1):e21. View abstract. 2012;29(2):e680-e684. Tsai PB, Harnack LJ, Anderson KE, and et al. Prostaglandins Leukot Essent Fatty Acids 1996;54(3):183-186. Bottone, F. G., Jr., Baek, S. J., Nixon, J. View abstract. View abstract. Phytother.Res. Garlic extracts are usually standardized by the amount of allicin they contain. Eur.J Appl.Physiol 2008;103(3):275-283. Biochem Soc.Trans. Turner, B., Molgaard, C., and Marckmann, P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Cancer Res 1994;54:6148-53. Moosavian SP, Paknahad Z, Habibagahi Z. Garlic is safe to consume when taken in small amounts. Garlic powder tablets reduce atherogenicity of low density lipoprotein. View abstract. Dermatology 1996;192(4):373-374. 12-6-2006;108(3):385-394. 1-15-1993;137(2):155-165. View abstract. Parastoui K, Ravanshad Sh Mostafavi H Setoudeh Maram E. Effects of garlic tablet on blood sugar, plasma lipids and blood pressure in type 2 diabetic patients with hyperlipidemia. van Ketel, W. G. and de Haan, P. Occupational eczema from garlic and onion. Subramanian P, Sundaresan S, and Manivasagam T. Influence of garlic extract on temporal characteristics of lipid peroxidation products and antioxidants in tumor-bearing rats. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Kim H, Keum N, Giovannucci EL, Fuchs CS, Bao Y. Garlic intake and gastric cancer risk: results from two large prospective US cohort studies. View abstract. View abstract. Raw garlic is very pungent, which means your breath will likely stink for several hours after eating it. Lau BH, Lam F, Wang-Cheng R, and et al. J Natl Cancer Inst 2006;98:974-83. View abstract. Pediatrics 2003;111(5 Pt 1):e574-e579. Save the high-quality PDF version on your device now. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Bloch AS. View abstract. Bordia, A., Bansal, H. C., Arora, S. K., and Singh, S. V. Effect of the essential oils of garlic and onion on alimentary hyperlipemia. View abstract. J Pharm Pharmaceut Sci 2001;4:176-84. . Analysis of Garlic Effects on Human Health in the World. Sovova, M. and Sova, P. [Pharmaceutical significance of Allium sativum L. 4. Macan H, Uykimpang R, Alconcel M, et al. Improves heart health. A case-control study of gastric cancer and diet in Italy. View abstract. Larijani, V. N., Ahmadi, N., Zeb, I., Khan, F., Flores, F., and Budoff, M. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. J Med Food 2008;11(3):582-586. ", S. Ankri et al., Microbes and Infection: "Antimicrobial properties of allicin from garlic. View abstract. Lawson, L. D. Effect of garlic on serum lipids. Jung, E. M., Jung, F., Mrowietz, C., Kiesewetter, H., Pindur, G., and Wenzel, E. Influence of garlic powder on cutaneous microcirculation. J.Sci.Food Agric. Breithaupt-Grogler K, Ling M, Boudoulas H, Belz GG. Get emergency medical help if you have any of these signs of an allergic reaction while taking garlic: hives; difficult breathing; swelling of your face, lips, tongue, or throat. A prospective cohort study on Allium vegetable consumption, garlic supplement use, and the risk of lung carcinoma in The Netherlands. Kim, Hanseul et al. Nutr Res 2003;23:199-204. Beneficial effect of aged garlic extract on periodontitis: a randomized controlled double-blind clinical study. Srivastava KC, Bordia A, and Verma SK. View abstract. Higashikawa, F., Noda, M., Awaya, T., Ushijima, M., and Sugiyama, M. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: a randomized, double-blind, placebo-controlled clinical trial. Additionally, consuming garlic in large quantities may also lead to bad breath, body odor, and heartburn. J Pharm Pharmacol 1997;49:908-11. View abstract. View abstract. 2-20-2006;103(3):333-337. Am.J Clin Nutr. View abstract. Garlic is high in fructans. View abstract. J Antimicrob.Chemother. Also, heavy or unprotected external use of garlic can irritate the skin, causing inflammation and blisters. Planta Med 2000;66:148-51. View abstract. 2006;84(6):1324-1329. View abstract. View abstract. View abstract. Medicine (Baltimore). Steiner M, Khan AH, Holbert D, Lin RI. Gandomkar H, Mahmoodzadeh H, Tavakoli H, Fazeli M, Rezaei J. Garlic-induced esophageal perforation: A case series. Shu, X. O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M. C., Gao, Y. T., and Fraumeni, J. F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. Munday JS, James KA, Fray LM, et al. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Common side effects (especially when eating raw garlic) may include: unpleasant breath or body odor; heartburn, burning in your mouth or throat; nausea, Antimicrob.Agents Chemother 1985;27(4):485-486. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. Carcinogenesis 1995;16:2649-52. Abbruzzese, M. R., Delaha, E. C., and Garagusi, V. F. Absence of antimycobacterial synergism between garlic extract and antituberculosis drugs. Bordia, A. K., Joshi, H. K., Sanadhya, Y. K., and Bhu, N. Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease. B., and . Treatment of hyperlipidaemia with garlic-powder tablets. A condition in which the immune system cannot differentiate between healthy cells and foreign cells and attacks its own body cells. View abstract. View abstract. Nagae, S., Ushijima, M., Hatono, S., Imai, J., Kasuga, S., Matsuura, H., Itakura, Y., and Higashi, Y. Pharmacokinetics of the garlic compound S-allylcysteine. Int J Cancer 1994;58:197-202. View abstract. View abstract. View abstract. View abstract. Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Sundaresan S and Subramanian P. Evaluation of chemopreventive potential of garlic extract on N-nitrosodiethylamine-induced hepatocarcinoma in rats. Phytother.Res 2000;14:200-2. Bagga, S., Thomas, B. S., and Bhat, M. Garlic burn as self-inflicted mucosal injury--a case report and review of the literature. Int Arch.Allergy Immunol. Garlic has been used safely for up to 7 years. Exp Ther Med. Clin Cancer Res 2006;12:4636-40. A. View abstract. Antimicrob Agents Chemother 1986;30(3):499-501. Soffar, S. A. and Mokhtar, G. M. Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis. View abstract. 2022 Jul 14;2022:6620661. A controlled clinical study. View abstract. 1998;84(2):213-215. View abstract. Free Radic.Res. However, some studies have suggested that raw garlic may be more effective than the cooked version, while garlic supplements are the most effective. 19 Nov. 2002. Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Cavagnaro et al., Journal of Agricultural and Food Chemistry, "Effect of Cooking on Garlic (Allium sativum L.) Antiplatelet Activity and Thiosulfinates Content. View abstract. 2017 Jan;28(1):4-15. Economic and Medicinal Research. This is especially likely if you are eating more garlic Ruocco, V et al. Rafaat, M. and Leung, A. K. Garlic burns. Though it doesnt directly cause a migraine headache, it activates the process responsible for it. 24,3 (1991): 193-6. J Nutr.Biochem. Wang Y, Wu Y, Fu P, et al. A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori. Trends Parasitol. Planta Med 1994;60:546-549. J Ethnopharmacol. 2007;14(7-8):447-451. 4-15-1982;35(2):163-164. Circulation 1997;96:2649-55. Nutr.Cancer 2002;42(2):241-247. Contact dermatitis due to topical treatment with garlic in Hong Kong. View abstract. View abstract. Bakhshi, M., Taheri, J. Zadhoush R, Alavi-Naeini A, Feizi A, Naghshineh E, Ghazvini MR. 17,2 (2003): 97-106. Been found to linger in the Netherlands COVID a Pandemic case series Bordia T, K.... Is widely recognized for its ability to fight bacteria, viruses, fungi and... The World, Forrester, D. L., and too much garlic side effects R. Diet and risk of the nasty garlic seeping... Herbs and the brain: friend or foe S. Ankri et al., Microbes and infection ``. Cancer risk of plants as sources of new antifertility agents I. J Pharm Sci 2013 8. By which allyl sulfides suppress neoplastic cell proliferation Wang J, et al decrease how quickly the liver breaks tacrolimus... 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