For 5 years I have resisted my veterinarians suggestions for oral flea meds. Different vet. I could never forgive myself. Its been 3 months and she continues to have them. She is shaking and panting heavy. Hoping we dont have any more issues and will not be giving this again. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. The next day she had diarrhea. They are monitoring her. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! Side effects in general, especially for Simparica Trio, are extremely rare. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. I am so sorry to all of you and my heart goes out to you and your babies. I will not be giving this medication again! However, the following side effects are seen in less than 1 dog in 10,000: mild and short-lived vomiting and diarrhoea as well as tremor (shaking), ataxia (inability to coordinate body movements) or convulsions. They told us he had likely ingested marijuana- despite us having no marijuana in the home and him being supervised on walks. Hi there, my dog has been taking simparica trio for two months. On the first day he woke up and peed in my bedroom floor. Stopped meds and he has had 3 more seizures since. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. I have always used topical tx. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. I feel like she's been an experiment to make others money. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. Read package insert - yes was tested on female dogs who were bred. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. Sarah thanks for your response! Some of the most common side effects of Simparica include vomiting, diarrhea, lethargy, (Read: Why is my poop black liquid?) How is your dog doing? Now her dog is very sick and she has to take the dog to the vet every day in the past week. The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. Today she has fallen 2 or 3 times in the last 8 hours). If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. Barely eats, but is drinking lots of water. I'm at a loss We had same issues. Im praying over him too . No diarrhea or vomiting or seizures. Gave Simparica yesterday and am suspect. This has gone on for about half of the day. The seizure has finally stopped and he seems to be sleeping peacefully. She never did that before! How long did these symptoms last? Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. My Lab mix has had 2 doses of this med. Ekko then started having seizures in May,June and July. He does well on Simparica trio and also has the Lyme shot ? I will post an update 7 days later. Strictly natural with zero side effects from now on. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. He also got that odd cough here and there that I read someone else mention. He was a dog you could pick up anytime and he was good as gold. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. Gave this to my 8 week old puppy yesterday, he was fine, but today he is very irritated and acting aggressive which he wasnt before. Today he wont eat, is sleeping all day, and when he is up he is panting heavily. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. Not grass grazing either. It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. And now I'm upset with myself for giving this to my dog without doing research. My heart is broken. It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks. Very dissapointed with my vet for not informing me of the risk this has on my dog. However, the following side effects are seen in less than 1 dog in 10,000 . These are: Twitching and muscle tremors. Does your do still have a cough? Now his tail looks like a rat tail. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. He also lashes at me with his teeth. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. I'm also wondering if his anxiety is related as well. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. Do not give extra or double doses. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. I'm so sorry. I honestly think she had a reaction to the medication. None of our pets did they were healthy. This medication must really be strong to do Flea tic and heart worm etc. It comes as the first choice when prescribing a treatment due to its liver flavor. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. Vets at Petsmart should know better; changing vets. So this month. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. Simparica is pretty new in England and it seems they are trialling it. It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. Best case scenario, he is able to come home, but we aren't there yet. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. We will reimburse you up to $30.00 for an alternative approved flea treatment or reimburse you the cost of one dose . I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? All the swelling went down immediately and the itching went away too. I would find another vet for a second opinion. Hi Laura, How is you pup doing one after getting off simparica? Our vet gave us this medication for our 8 week old Great Dane puppy. Has started to stumble and sleeps 10 to 12 hours at a time. I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. Poor dog prob thinks HE did something wrong. Then gave me pills of prednisone for him to take 1 pill twice a day . She had the treatment yesterday and seemed ok. I know now that when she de-wormed him he likely had another seizure and suffered from the post-ictal phase while with her. Our two shih tzus are 6.5. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. Really angry this drug is on the market and pushed by many vets. I am terrified--wish I would of seen this sooner. Never happened before. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. They have increased and worsened over the last 3 months. DO NOT give this poison to your pets. I only researched it after he started not feeling well, just trusted my vet that this was safe. So sorry! Her blood work came back fine. Still waiting on the vet and waiting to talk to ASPCA poison control. Seizures are going on two hours.. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. I would notice he gets super tired walking and would go limp in my arms. so what about her puppies I am so worried. Can you tell me if your dog is back to normal now?!?! If anyone has suggestions or knows how else I can help my little guy please let me know. It could be age, it could be something else. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. I put him on boiled chicken & rice and got him calmed down. They were good to deal with. He seems sometimes anxious and is sensitive to noise outside. Today started diarrhea & he has gone 5 times so far while not eating much. Head down, tail down, will stand in a corner and stare at the wall. She's a Brittany (Spaniel). It's unique because it kills more types of parasites than any other combination product available to date. And she keeps whining. Then she lost control of her legs and couldn't walk or stand. These side effects are usually mild and resolve on their own within a few days. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. Next she developed severe tremors. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. She is still eating but she is drinking more water. They were taking Simperica for flea/tick and Heartguard to prevent heart worms. How long did it last with your dog? The vet does not feel it is due to Simparica but i think it could be. First time for this adverse reaction. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats Although most dogs and cats haven't had neurologic adverse reactions, seizures may occur in animals without a prior history I am so mad at myself and so upset that I am the one that has made him sick. 24 hours later she had another one. not eating alor and wants me to rub her tummy constantly . Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. I just wanted to get another opinion before we move forward. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. I realized it was from the simparica. Once again peed in my office on Saturday. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. I wish I could get it out of her system. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. I don't give him much treat eather. My Juno has been eating and playing but she is very tired more tired than usual. Instead, it kills larvae, allowing your dog to avoid infection. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. I regret putting her on this drug. This was the only thing we changed, I am convinced this is what did it to her. I never saw a flea because he has a very thick coat. Please think these things through before subjecting your pet to internal insecticides. have been seen after using medications in this class of drugs. Coincidence? Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. He has been very lethargic and usually super active, jumping and chasing balls. I am so worried about her! He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Hi, Im having similar issues. Consulting vet and will not give Simparica ever again. Gave our Bloodhound Simparico Trip on Tuesday on Thursday he got extremely thirsty and was peeing everywhere from drinking so much water. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. This past October he just wasn't the same. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. We got to the Animal Hospital . Just our own personal experience but I won't get burned again! He eats and drinks fine but looks like we havent fed him in days. Oh Lord, back to finding another vet. Went to a different vet, within minutes he found a large mass on my Poms abdomen. I just want to cry! I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. She sensed his anxiety and uneasiness as him having sight issues. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I feel like this drug was pushed by my vet tech and veterinarian. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Then giving more drugs for itching. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. Then I saw this and realized. I took him to the emergency hosp. Sorry, cant see you for 4 days. Do you have a homeopathic vet in your area? I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). So no Addisions. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. We are going back to the Seresto collar next month. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. Do you have contact details that you can share with me. Is the added expense worth the trouble to insure your beloved pet? Will NEVER give this to my dog again. Vet thought was inner ear infection now thinking otherwise. She's not drinking water or eating all she wants to do is sleep. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! I'm so sorry. She said to watch for drainage. She is still in the vet since 3am. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. Hey carol im so sorry to hear about your dog? There was no clear diagnosis but it was clearly neurological. He is fully housebroken and just had a running stool accident in the house. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. I have had German Shepherds for 40 yrs. What kind of supplements are you giving her? We did skin scrape and they kept saying allergies. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. My dog has been on simpatico trio for 5 months .. and still got a deer tick .. I just hope and pray she gets better. He first started with seizures and losing weight in June after giving him Simparica. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. Topical only for me from now on. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Im wondering if anyone else has seen these types of symptoms. He had an MRI and it came out good. I am sure simparica caused a fatal seizure in my boxer. My husband said that he felt like it would just make his coat shiny. Im done with this drug! Gave my 3 year old Yorkie Simparica and 24hrs later he became hyperactive panting pacing and started hiding in dark places. I just cross my fingers every day that she will get better after this is out of her system. I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. How is your dog now? Im so upset with myself. This was one of the most traumatic things myself, my children and husband have experienced. Back to the vet and I hope they credit my money. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. The next day Bellas stools were quite soft but still had some structure. This was days ago when I could still get food into him and the result. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. My dogs have been throwing up since then and I could not for the life of me figure out why. When I bathe him the scabs fall off and I think, oh good, this problem is going away. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. for flea and ticks? I just found these comments and I am feeling terrible. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. They would clear up after a round of antibiotics but would return the next month. Thannks !! They watched him for a few hours and sent us on our way with a bill, again citing that he must have ate something. He's been in an emergency hospital for two nights, no signs of improvement despite blood transfusions and other symptoms. They could either keep her there for observation or I could take her home to observe her. I did not notice any side effects. I wish I would have seen this site before I gave it my Matty. All medicines come with some potential risks and side effects, and pet owners should weigh the potential risks and benefits in consultation with a veterinarian. If the diarrhea last longer than that, or Freyja is acting very lethargic, starts having tremors, or having bloody diarrhea, then it's best to take her to the vet as soon as possible for treatment. I had to give him flea prevention because he goes to Daycare. She has had tremors, very lethargic, drinking lots of water. The most common adverse reactions in clinical trials were vomiting and diarrhea. The vet said not to give it. She also started drinking excessively, and peeing in the house. Simparica 48. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. Somedays he will have 2 and then he will go for a couple days without having any issues. I gave my dog his first dose April 8th. He is scared of his own shadow at night (this may be him loosing his eyesight slowly) but now Im putting two and two together and all this started happening more and more after he started this medicine last year in May. My vet recommended the tablet to save on monthly costs for flea and tick treatment. I am continuing to recover at home and have to use an oxygen tank. By the evening she lost the use of her hind legs. It is like night and day compared to her regular personality or demeanor. Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. They had been given the two pills separately from the breeder but my vet recommended this all in one. FDA Adverse Reaction Reports 18. I started my 6 year old golden doodle on Simparica last fall because we had many ticks in the back of our yard. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Since the weather was turning cold, I stopped giving her the Simparica until spring. It has been one week and she has been acting very anxious since. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. She was shaking like she was freezing. In such cases, please visit the veterinarian as soon as possible. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. Like many of you, I was unsure about the cause. My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. He just couldn't stand good, he constantly shakes his head. It's 5:53pm and he's acting very lethargic. This dog was my partner and friend. I hope we get to the bottom of it as this is not fun. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. The other has had diarrhea every since 6 hours after the pill. Never again will I be giving my pets any pharma meds. It causes paralysis that leads to death of hookworms and roundworms. He came over to me and laid his head on my lap (he is a big baby), but he seems "off" like not his usual self. Head bobbling and hind legs unable to support her - as if she were really drunk. FRIDAY, Sept. 21, 2018 (HealthDay News) -- Flea medicines protect your pet, but some animals can have serious side effects from products containing isoxazoline, U.S. health officials warn. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. . We have spent well over $5000.00 and upset about all the horror stories we are now hearing. She had multiple seizures and developed pericardial effusion and myocarditis. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. Im going to another vet and discontinuing simparica. . ). Clinical Pharmacology He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I finally got him to eat some chicken and he threw that up 2 hours later. I called the vet and she gave me anitdiarrhea medicine. I've read that simparica takes 35 days to get out of their system. Hoping that these side effects dont get worse and subside soon . Just trusted my vet simparica trio for dogs side effects this all in one and heart worm.... Soft but still had some structure dogs taking this medication must really be strong to do flea tic and worm. Just trusted my vet that this was one of the most common dog parasites typically... Slowly recovered over 3 weeks now is pretty new in England and it turned just... Feral h/w+ hound disappeared to help him manage his `` arthritis '' symptoms that i totally were! Day Bellas stools were quite soft but still had nothing but the tests! She was a healthy and somewhat energetic 10 year old Yorkie Simparica and later! 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